New York Knicks vs San Antonio Spurs Prediction & Prop Bets – 12/31/2025

Wednesday night’s NBA slate closes out 2025 with a highly anticipated regular-season matchup between the New York Knicks and San Antonio Spurs. Both teams have been among the league’s top performers this season and enter this game having recently faced each other in the NBA Cup final. San Antonio is a slight favorite at home, as they look for revenge against the Knicks in this contest. Before tip-off in Texas, continue reading to find my Knicks vs Spurs prediction.

Our Knicks vs Spurs Pick

Game Snapshot

• Matchup: New York Knicks @ San Antonio Spurs
• Date & Time: Wednesday, December 31, 2025, 7:00 PM ET
• Venue: Frost Bank Center, San Antonio, Texas
• Broadcast: NBA TV

Key Storylines

Injuries are a key concern for both teams heading into New Year’s Eve play. San Antonio will be without Devin Vassell, ruled out with an adductor strain, and guard Stephon Castle is listed as questionable with a sprained thumb. Those absences could impact spacing and guard play for the Spurs. New York is also managing its own concerns, with starter Josh Hart out, Landry Shamet sidelined, and Mitchell Robinson listed as out due to ankle issues.

This game is a rematch of the teams’ recent NBA Cup final, where the Knicks came away with a 124-113 victory, showing they can handle the Spurs’ versatility when at full strength on a neutral court. San Antonio will look to respond in this game on their home floor, where the Spurs are 11-4 on the season. Victor Wembanyama has been playing on a minutes restriction after returning from a calf injury, which adds another item to monitor going into this contest.

Every time these teams play right now, expect a little bit of added intensity, as they could meet in the NBA Finals later in the season. Both of these teams have played some of the best basketball in the league this year and will try to continue doing so in this measuring stick game from San Antonio.

Head-to-Head & Betting Trends

• The Knicks won the first meeting between these teams this year in the NBA Cup final.
• The Knicks are 18-15 against the spread so far this season.
• San Antonio is 17-14-2 against the spread going into this contest.
• The Knicks have gone over the total 19 times in 33 games.
• The under has cashed in 17 of San Antonio’s first 33 games.

Best Player Props to Watch

Knicks vs Spurs Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.