Memphis Grizzlies vs Los Angeles Clippers Prediction – 12/15/2025

The Memphis Grizzlies head to Southern California on Monday night to take on the LA Clippers. Both teams have endured rough starts to their seasons and are searching for some traction to help them climb back into the top 10 in the Western Conference. Before these two desperate teams do battle out West, you can find my breakdown of this game below, including my Grizzlies vs Clippers prediction.

Our Grizzlies vs Clippers Pick

Game Snapshot

• Matchup: Memphis Grizzlies @ Los Angeles Clippers
• Date & Time: Monday, December 15, 2025, 10:30 PM ET
• Venue: Intuit Dome, Inglewood, California
• Broadcast: NBA League Pass

Key Storylines

The outcome of this contest is going to depend heavily on injuries and roster availability. Memphis will be without center Zach Edey, who is sidelined for at least four weeks with a left ankle stress reaction, robbing them of a productive inside presence and rebounding force. Several other Grizzlies, including Ty Jerome, John Konchar, and Javon Small, are also listed as out or doubtful.

Ja Morant recently returned from a calf strain and scored 21 points in a loss to the Utah Jazz. Cedric Coward and Cam Spencer have also contributed against the Clippers in their last meeting and have seen their roles in the Memphis offense increase with all of the injuries surrounding the team.

Los Angeles enters the game dealing with its own injury issues. Bradley Beal is out for the season, while James Harden and Nicolas Batum are listed as questionable with a calf contusion and illness, respectively. Derrick Jones Jr. remains sidelined as well, reducing the Clippers’ depth. The Clippers have struggled to string wins together this season and they will try to snap a three-game losing streak here.

Head-to-Head & Betting Trends

• In their last two meetings this season, the Grizzlies secured wins over the Clippers in both games. Memphis got a 112‑107 road victory and a 107‑98 home win against LA earlier this season.
• The Clippers are 8-17 against the spread this season. They are tied for the fewest wins in the league against the spread this year.
• Memphis is 11-14 against the spread this year.
• The Clippers have gone 13-12 on over/unders this season, slightly favoring the over.
• Memphis has gone under the total in 16 of their 25 games.

Best Player Props to Watch

Grizzlies vs Clippers Model Projection

Final Thoughts

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.