Indiana Pacers vs Philadelphia 76ers Prediction – 12/12/2025

The Indiana Pacers will travel to Philadelphia on Friday for an Eastern Conference contest with the Philadelphia 76ers. The Pacers come into this game with a rare bit of momentum on their side, while the Sixers will try to take advantage of some of their key players being on the floor together. Before tip-off from Philly, keep reading to get my breakdown of this matchup and to get my Pacers vs 76ers prediction.

Our Pacers vs 76ers Pick

Game Snapshot

• Matchup: Indiana Pacers @ Philadelphia 76ers
• Date & Time: Friday, December 12, 2025, 7:00 PM ET
• Venue: Xfinity Mobile Arena, Philadelphia, Pennsylvania
• Broadcast: NBA League Pass

Key Storylines

Philadelphia enters this game trying to find consistency on both ends. The 76ers are coming off a loss to the Lakers where Joel Embiid shot poorly and Paul George struggled to make a major impact. Tyrese Maxey, however, has been excellent this season, averaging over 31 points and more than 7 assists per game. Maxey has become the focal point of the team’s offense. The status of Kelly Oubre Jr. remains in question, impacting perimeter shooting and defensive versatility. Embiid and Maxey are also listed as questionable for this contest.

For the Pacers, recent games have shown improvement, with Bennedict Mathurin returning and delivering 25 points in a recent win over Sacramento and Andrew Nembhard posting strong numbers. Indiana has struggled this season overall, ranking low in both offensive and defensive efficiency, but they are starting to get healthier and have won two games in a row going into this contest. The absence of Ben Sheppard and Aaron Nesmith continues to limit their depth. But having Mathurin back on the floor has been a huge positive for this team.

Head-to-Head & Betting Trends

• This is the first game between the 76ers and Pacers during the 2025-26 season.
• These teams will play a total of four times during the regular season this year.
• The 76ers are 13-10 against the spread so far this season.
• Pacers are 13-11 against the spread to this point in the season.
• The under has hit in 12 of the 23 games the Sixers have played in this year.
• Indiana has gone 9-15 in the over/under market for the season.

Best Player Props to Watch

Pacers vs 76ers Model Projection

Final Thoughts

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Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.