New York Yankees vs Boston Red Sox Prediction: Yankees Look For Another Win Over Rivals
Updated April 22, 2026
Updated April 22, 2026
The rivalry between the New York Yankees and Boston Red Sox resumes Wednesday night at Fenway Park. New York enters at 14-9 and sits atop the AL East, while Boston has stumbled to 9-14 and is trying to get back on track after some inconsistent play. The Yankees opened the series with a 4-0 shutout win, backed by strong pitching and timely power hitting. Before the second game of their series begins, continue reading for my Yankees vs Red Sox prediction for Wednesday.
Score Projection: Yankees 5 - Red Sox 3
Win Probability: Yankees 62%, Red Sox 38%
The numbers point clearly toward New York in this spot. Max Fried brings elite command and run prevention into a favorable matchup against a Boston lineup that has struggled to generate consistent offense. The Yankees also carry the stronger bullpen and are producing more runs overall, with 114 runs compared to Boston’s 89. Expect another solid performance from the Yankees, with enough offense to separate themselves late. I'll take New York to get the win on the moneyline here, as they should win another relatively low-scoring contest from Fenway.
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