Old Dominion Monarchs vs South Florida Bulls Cure Bowl Prediction – 12/17/2025

The Old Dominion Monarchs and South Florida Bulls will meet in the Cure Bowl on Wednesday night. Both teams went 9-3 this season and will try to get a 10th win to close out their season in this matchup. But these teams will look very different than they did during the regular season. Here, I break it all down and give you my Old Dominion vs South Florida prediction in college football.

Our Old Dominion vs South Florida Pick

Game Snapshot

• Matchup: Old Dominion Monarchs vs South Florida Bulls
• Date & Time: Wednesday, December 17, 2025, 5:00 p.m.
• Venue: Camping World Stadium, Orlando, Florida
• Broadcast: ESPN

Key Storylines

Both Old Dominion and South Florida arrive in Orlando with nine-win seasons but have some major personnel changes that could dramatically influence this matchup. Each team’s starting quarterback will sit out this bowl game, shifting responsibilities to backups with limited experience at the helm.

South Florida’s Byrum Brown, who threw for well over 3,000 yards and ran for over 1,000 on the season, has opted out of this game, leaving Gaston Moore to start. Old Dominion’s Colton Joseph also accounted for high yardage totals in both the air and on the ground. He is sitting out as well, with Quinn Henicle stepping in. These changes will likely reduce offensive explosiveness and elevate the importance of game management and clock control from both units.

Quarterback Play

At Old Dominion, Quinn Henicle will make his first start after Joseph’s departure. Henicle has minimal collegiate passing experience but has shown agility and toughness when called upon. South Florida’s Gaston Moore will take snaps in place of Brown, whose dual-threat offensive production was a cornerstone of the Bulls’ high-scoring attack. The lack of continuity at the most important position likely points to conservative play calls early and a heavier reliance on running games and short passes to settle the offenses into a rhythm.

Betting Trends

• Old Dominion is 7-5 against the spread going into the Cure Bowl.
• South Florida is 8-3-1 against the spread entering this matchup.
• The under has cashed in 8 of the first 12 games of the season for Old Dominion.
• South Florida is 7-5 on over/unders going into bowl season.

Old Dominion vs South Florida Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.