Duke vs Syracuse Pick & Prediction - 9/27/2025
Updated September 24, 2025
Updated September 24, 2025
The Duke Blue Devils and Syracuse Orange will square off on Saturday in Central New York. Both teams got impressive wins in their ACC openers in their last outings. They will look to improve to 2-0 in conference play with a win in this matchup. Before the Blue Devils and Orange do battle in Syracuse, continue reading to get my Duke vs Syracuse prediction for this weekend.
Spread | Moneyline | Total (O/U) |
|---|---|---|
Duke −5.5 | Duke –215 / Syracuse +180 | 60.5 |
Duke’s Darian Mensah is one of the more reliable passers in college football this year. He has been both efficient and explosive through Duke's first four games and will try to continue to have success in this contest. Syracuse is in uncharted territory with its quarterback situation. With Angeli out, Collins will need to lean heavily on short drops, checkdowns, and help from the Syracuse run game. But things could work out for them if Collins adjusts quickly to his role as the starter.
Score Projection: Duke 38 – Syracuse 28
Win Probability: Duke 65%, Syracuse 35%
I think that Syracuse will still showcase some offensive firepower even without Angeli to lead them from the quarterback position. While Duke should win the game given all of the adversity that the Orange have to overcome, I think the best bet for this matchup is for the game to go over the total. We should see these teams combine to score over 60 points here, with Duke doing the majority of the scoring in what should be a fun contest between teams looking to stay unbeaten in ACC competition.
