Syracuse Orange vs Kansas Jayhawks Prediction - 11/25/2025

Syracuse and Kansas will square off Tuesday at the Players Era Festival in Las Vegas. The Orange are playing without their leading scorer, and will look to test Kansas’ frontcourt dominance. Here, I take a closer look at this matchup between programs that have a history against one another and you can find my Syracuse vs Kansas prediction below.

Our Syracuse vs Kansas Pick

• Pick: Kansas -3.5
• Confidence: ★★★☆☆

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Game Snapshot

• Matchup: Syracuse Orange vs Kansas Jayhawks
• Date & Time: Tuesday, November 25, 2025, 8:30 PM ET
• Venue: MGM Grand Garden Arena, Las Vegas, Nevada
• Broadcast: TNT

Key Storylines

• Syracuse’s offensive anchor injured: Donnie Freeman, the Orange’s leading scorer at 17.8 PPG, is out of the tournament with a lower-body injury. His absence creates a major void in scoring and leadership.
• Depth steps up for Syracuse: With Freeman out, players like Tyler Betsey, JJ Starling, and William Kyle III will need to carry more of the offensive load. Their ability to produce efficiently will be key.
• Kansas’ paint dominance: Freshman Flory Bidunga continues to impress for Kansas. He posted 18 points, 9 rebounds, 5 assists, and 5 blocks in Kansas’ most recent win. His presence inside gives Kansas a clear edge.
• Missing perimeter firepower for Kansas: Kansas is without Darryn Peterson, their top guard. But they’ve leaned on defense, rebounding, and strong execution to compensate for his absence.
• Back-to-back fatigue factor: Both teams are playing consecutive days in Las Vegas, which could lead to sluggish legs, especially late. Syracuse played an overtime game against Houston last night and fell short, while Kansas beat Notre Dame by 10 points.

Head-to-Head & Betting Trends

Past meetings: The two programs have limited recent history. Their most recent clash was back in December 2017, when Kansas won 76-60.

ATS trends: Kansas is 3-3 against the spread going into this matchup. Syracuse has covered the spread in four of its first five games.

Over/under trends: The under has hit in three of the first five games for Syracuse. The under has cashed in five of the six games the Jayhawks have participated in.

Syracuse vs Kansas Model Projection

Score Projection: Syracuse 70 – Kansas 76

Win Probability: Syracuse 37%, Kansas 63%

Final Thoughts

Both teams are missing important players going into this contest. But Kansas appears to be the best-equipped to win this game when playing for the second day in a row. Expect the Jayhawks' interior presence to make it tough for Syracuse to get good looks in the paint and for that to help Kansas win this game by a couple of possessions in Las Vegas.

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