Iowa State (5-0) looks to build on Monday’s thrilling 83–82 win over St. John’s as they take on Creighton (3-2) on Tuesday in the Players Era Festival in Las Vegas. The Cyclones will look to get a second win over a Big East team in as many days with a win here. Before tip-off from Las Vegas, you can find my Iowa State vs Creighton prediction below.
Our Iowa State vs Creighton Pick
Pick: Creighton +8.5
Confidence: ★★★☆☆
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Game Snapshot
- Matchup: Iowa State Cyclones @ Creighton Bluejays
- Date & Time: Tuesday, November 25, 2025, 2:00 PM ET
- Venue: Michelob ULTRA Arena, Las Vegas, NV
- Broadcast: truTV
Key Storylines
- Lipsey injury concern: The biggest question hanging over this game is whether guard Tamin Lipsey can play for Iowa State. He exited late in Monday’s win over St. John’s with a lower-body issue and is being evaluated day to day. His health will likely shape how Iowa State attacks the Creighton defense.
- Cyclone offense rolling: Iowa State is playing with pace and efficiency, averaging 93 points per game and creating plenty of turnovers. They thrive in transition, and that could be a big problem for a Creighton team that has struggled against upper echelon programs so far this year.
- Coaching duel: This is a battle between two well-respected coaches with a friendship. The friendly rivalry adds a little extra juice to this game.
- Creighton’s identity shift: The Bluejays are adjusting after roster turnover. Without last year’s leading scorers like Ryan Kalkbrenner, they lean more on a balanced attack this season. Players like Blake Harper and Nik Graves will need to step up.
- Early Start In Vegas: This game starts at 11:00 AM Pacific Time. That is an early start time than usual for these players to deal with and it will be interesting to see how the performance of both teams on the floor is impacted by that.
Betting Trends
- Iowa State is 3-1-1 against the spread so far this season.
- Creighton is 1-4 against the spread going into this matchup.
- Iowa State is 4-1 to the over through five games this year.
- All five of Creighton’s games this season have gone under their totals.
Iowa State vs Creighton Model Projection
- Score Projection: Iowa State 79 – Creighton 74
- Win Probability: Iowa State 65%, Creighton 35%
Final Thoughts
Iowa State should still be able to win this game despite the injury concerns surrounding Tamin Lipsey. But I’m going to take the points with Creighton in this matchup. The Bluejays hung around against Baylor for the most part yesterday and they should be able to do the same in this contest against a banged-up Iowa State team on the second game of a back-to-back in Vegas.
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