St. Louis Blues vs Buffalo Sabres Prediction - 11/6/2025
Updated November 6, 2025
Updated November 6, 2025
The St. Louis Blues will face the Buffalo Sabres on Thursday night KeyBank Center in Buffalo. Both of these teams have struggled early in the year and will try to get a win to bring them out of their recent funks here. Before the puck drops in Buffalo, continue reading to get my Blues vs Sabres prediction for Thursday night.
Buffalo sits at 5-4-4 entering this game. They have lost four of their last five games, but all five of those games have yielded at least a point for Buffalo. They need to be better at closing games, especially in overtime, but things aren't as bad as the win/loss record would indicate for the Sabres of late.
St. Louis arrives at 4-8-2 after a 6-1 loss to the Washington Capitals in their last game. They’re averaging only 2.71 goals per game and allowing 4.14 goals per game, which ranks them near the bottom of the league defensively. St. Louis has lost four of its last five games as well and will try to end that run with a strong performance in this game.
Alex Lyon is likely to start this game in net for the Sabres. He enters this game at 3-4-3 with a 2.81 GAA and .915 save percentage. St. Louis' Jordan Binnington is 3-5-2 with a 3.34 GAA and .859 save percentage. But we could see Binnington replaced here as the Blues are on the second game of a back-to-back as they travel in from Washington overnight.
St. Louis:
Buffalo:
Player | Stat | Prop |
|---|---|---|
Alex Tuch (Sabres) | Points | Over 0.5 |
Tage Thompson (Sabres) | Goals | Over 0.5 |
Jordan Kyrou (Blues) | Goals | Over 0.5 |
Score Projection: Buffalo 4 – St. Louis 2
Win Probability: Buffalo 65%, St. Louis 35%
The Sabres should have the upper hand against the Blues in this contest. St. Louis is at an extreme rest disadvantage and had to travel to Buffalo overnight for this game. I'll take the Sabres to win on the moneyline at home as they should take advantage of the fatigue surrounding this St. Louis team.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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