Tampa Bay Buccaneers vs Buffalo Bills Prediction - 11/16/2025
Updated November 14, 2025
Updated November 14, 2025
The Tampa Bay Buccaneers (6-3) head to Highmark Stadium in Orchard Park on Sunday to face the Buffalo Bills (6-3). Both teams have identical records and are both coming off a loss in their last game. Buffalo is a home favorite in this contest and will try to continue its winning ways at home. I have broken this game down from all angles and you can find my Buccaneers vs Bills prediction below.
The Bills are very hard to beat at home. They’ve won 14 of their last 15 games at Highmark Stadium, a tremendous .933 home winning percentage over that span. The Buccaneers come into this game with a record of 4-1 on the road this year. Both teams have thrived in these situations going into this game, but only one of them can get a win in this matchup.
The Buccaneers are coming off a loss to the New England Patriots in which they allowed multiple big plays and struggled on third down. Their defense has surrendered three touchdown runs of 55+ yards recently and the offense went just 5/13 on third down in last week’s 28-23 loss.
The Bills were humbled last week by the Miami Dolphins in a 30-13 defeat that came despite the Bills being heavy favorites. The fact that both teams are coming off poor efforts makes this a bounce-back opportunity game for both sides with high stakes for both teams.
Bills QB Josh Allen is still the central piece of their offense. He has thrown for 2,139 yards with 15 touchdowns and 5 interceptions. Allen is also a great runner and will use his mobility to move the Bucs' defense around.
The Bucs’ signal-caller is Baker Mayfield, who has had a strong season in Tampa Bay’s balanced offense. But he’ll face a Bills defence that forces turnovers and thrives at home. The Bucs need to get Mayfield into rhythm with clean protection to help him stay at just two interceptions for the season.
Score Projection: Buffalo Bills 27 – Tampa Bay Buccaneers 20
Win Probability: Bills 68%, Buccaneers 32%
I'll take the Buffalo Bills to win and cover the spread as a favorite over the Bucs. Buffalo has been consistently good at home over the last couple of years, beating some of the best teams in the league at Highmark Stadium. They should do it again here and keep themselves within striking distance of the Patriots in the AFC East standings.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
Affiliate Disclosure
ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
