San Francisco 49ers vs Philadelphia Eagles Wild Card Prediction & Odds - 1/11/2026
Updated January 4, 2026
Updated January 4, 2026
The Philadelphia Eagles will host the San Francisco 49ers in the Wild Card round in the NFC playoffs. These teams have both made runs to the Super Bowl in recent seasons and one of them will move a step closer to reaching that stage with a win here. Before this contest kicks off, you can continue reading to get my analysis for this game as well as my 49ers vs Eagles prediction.
Pick: | Eagles -3 |
Confidence: | 4/5 |
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Odds | |
|---|---|
Spread | Eagles -3 |
Moneyline | Eagles -170, 49ers +142 |
Total | 46.5 points |
Jalen Hurts steered the Eagles to an 11–6 record while putting up solid numbers both through the air and on the ground. Hurts’ experience and resilience in big games will be critical against a tough San Francisco defense. We can also expect Hurts to get involved in short-yardage rushing situations, where his physicality is often too much for opposing defenses to handle.
The 49ers’ Brock Purdy has had an up-and-down ending to the regular season, including a shoulder stinger sustained in Week 18 that left question marks for his status ahead of the postseason. His mobility and decision-making will be tested by an Eagles front that finished the season with a strong pass rush and has proven it can beat playoff opponents.
Score Projection: Eagles 27 – 49ers 23
Win Probability: Eagles 58%, 49ers 42%
I am going to lay the points with the Eagles on Wild Card Weekend against the Niners. Philly doesn't always look great on offense, but they have shown up when it matters most on that side of the ball. Look for the Eagles to do enough on offense and for their defense to take advantage of Purdy's injuries to cover the spread and move into the Divisional round.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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