Los Angeles Rams vs San Francisco 49ers Pick - 11/9/2025
Updated November 6, 2025
Updated November 6, 2025
The Los Angeles Rams and San Francisco 49ers will play one another in Week 10 of the NFL season on Sunday. The Rams come in at 6-2 after a convincing 34-10 win over the Saints. The 49ers sit at 6-3 after a win over the New York Giants. The winner of this game will be ahead of the loser in the NFC West standings. Below you will find my Rams vs 49ers prediction for this huge game in the NFC playoff race.
Los Angeles has won three games in a row coming into this week. They have shut down the Ravens, Jaguars, and Saints over those three games. This will be a bigger challenge for Los Angeles as they look to prove that their defense can also stand up to teams in the playoff hunt. The Rams are 3-1 on the road so far this season and will try to pass their biggest road test of the season to date here.
The 49ers defeated the New York Giants on the road last week to get to 6-3. They’ve been hit hard by injuries on defense. Losing Nick Bosa early in the year was tough and the loss of linebacker Fred Warner might be even more damaging. San Francisco’s defense has given up big plays through the air recently. The Niners will have to get pressure on Matthew Stafford to prevent him from having time to complete throws down the field.
Matthew Stafford looks healthy and confident again. His four-touchdown day against New Orleans last week showed the kind of precision and rhythm that made him one of the league’s top quarterbacks throughout his career. The Rams can beat anyone if they protect Stafford and give him time to stretch the field vertically.
Brock Purdy is dealing with a toe and shoulder issue. He’s expected to start but the Niners could turn to Mac Jones if Purdy isn't at 100%. Both quarterbacks for the 49ers are serviceable and they have the help of the dynamic Christian McCaffrey out of the backfield to make things easier on them.
Projected Score: Rams 27 – 49ers 24
Win Probability: Rams 62% | 49ers 38%
I would be shocked if we didn't see another very close game between these two NFC West teams. The Niners are dealing with some major injuries on defense. But I am still going to take the points with San Francisco in this game. This feels like a field goal game no matter which team gets the win in Santa Clara.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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