Indianapolis Colts vs Los Angeles Chargers Prediction - 10/19/2025
Updated October 15, 2025
Updated October 15, 2025
The Indianapolis Colts (5-1) will hit the road to take on the Los Angeles Chargers (4-2) in Week 7 on Sunday. Both of these teams are above the .500 mark for the season and looking for a statement win against a fellow playoff contender in the AFC. Which team will get that win? Continue reading to get my Colts vs Chargers prediction for Sunday afternoon.
Odds | Line |
|---|---|
Spread | Chargers –1.5 |
Moneyline | Chargers –125, Colts +105 |
Total | 48.5 points |
Daniel Jones has been efficient for Indianapolis, showing good decision-making and benefiting from the presence of a strong rushing attack that takes pressure off him. He has thrown for over 1,500 yards with eight touchdown passes and just three interceptions. The Colts’ offensive line has also done a solid job protecting him.
Justin Herbert is elite when healthy. In the Chargers' Week 6 win over Miami, he completed 76.3% of his passes for 264 yards and two touchdowns. He is up to 10 touchdown passes to four interceptions for the season. The Chargers will lean heavily on Herbert to overcome their deficiencies elsewhere.
Score Projection: Colts 24 – Chargers 27
Win Probability: Colts 48%, Chargers 52%
This is going to be a very close game between two teams that we could see in the playoffs this season in the AFC. It is going to come down to which quarterback does the best job of delivering in key passing downs and avoids turnovers the most effectively. I think that quarterback will be Justin Herbert and that the Chargers will get the win on their home turf. I'll lay the points with Los Angeles in what should be a fun game from Inglewood.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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