Buffalo Bills vs Carolina Panthers Prediction - 10/26/2025
Updated October 23, 2025
Updated October 23, 2025
The Buffalo Bills will hit the road to take on the Carolina Panthers in Week 8 of the NFL season on Sunday. Buffalo lost two games in a row before they had their bye week. They will try to bounce back after a much-needed week off against a Panthers team that has exceeded expectations in the first half of the season. Before kickoff from Charlotte, you can find my breakdown of this game below, including my Bills vs Panthers prediction.
Spread | Moneyline | Total |
|---|---|---|
Bills −7.5 | Bills −400, Panthers +300 | Over/Under 45.5 |
Score Projection: Buffalo Bills 27 – Carolina Panthers 21
Win Probability: Buffalo 68%, Carolina 32%
The Bills should take advantage of Carolina's quarterback situation and their rest advantage to get a win in this contest. But I think that the Panthers will continue to surprise by covering the spread in this matchup. Dalton isn't a huge downgrade from Bryce Young at this stage of Young's development. I'll take the Panthers to keep this game within one score, even if Buffalo hands the Panthers their first home loss of the season.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
Affiliate Disclosure
ATS.io uses affiliate links. If you sign up through a link on this page, we may earn a commission at no additional cost to you. Rankings are based on hands-on testing and published criteria, and affiliate relationships do not determine placement.
