Philadelphia 76ers vs Memphis Grizzlies Pick & Prediction – 12/30/2025

The Philadelphia 76ers head to Memphis for a Tuesday night contest against the Grizzlies looking to halt a three-game losing streak, while a banged-up Memphis roster tries to defend its home court. Both teams enter this game at FedEx Forum occupying play-in tournament positions in their respective conferences. Who will get the win on Tuesday night? Continue reading to get my 76ers vs Grizzlies prediction in the NBA.

Our 76ers vs Grizzlies Pick

Game Snapshot

• Matchup: Philadelphia 76ers @ Memphis Grizzlies
• Date & Time: Tuesday, December 30, 2025, 8:00 PM ET
• Venue: FedExForum, Memphis, Tennessee
• Broadcast: NBC

Key Storylines

Philadelphia arrives in Tennessee amid a three-game losing streak with cracks showing on both ends of the court. Star big man Joel Embiid is questionable with an ankle injury, and Kelly Oubre Jr. is also out for the Sixers. The injury to Embiid’s ankle is the latest ailment for him and the Sixers will need to overcome that adversity once again.

Memphis has been consistently dealing with injury setbacks with a lengthy list of players out, including interior pieces like Zach Edey. Despite those losses, Memphis has hovered near .500 and will rely on their healthy stars to keep pace in a game with the Sixers that is expected to be close.

These teams are close to identical from a statistical point of view. They score and allow almost the same point totals per game, while both teams shoot 45% from the field. The team that can find some extra efficiency from the field in this game will give their team the upper hand in this inter-conference matchup.

This contest is the final home game for the Grizzlies before the head to Los Angeles for two games against the Lakers. If the Grizzlies drop this game, there is a very real chance that they lose the next two games on the road, heightening the sense of urgency for Memphis going into Tuesday night.

Head-to-Head & Betting Trends

• This is the first of two regular-season games set between the Sixers and Grizzlies.
• The 76ers are 17-13 against the spread going into this matchup.
• Memphis has a 15-17 record against the spread this season.
• Philly is 15-15 in the over/under market so far this year.
• The Grizzlies have stayed under the total in 20 of their first 32 games.

Best Player Props to Watch

76ers vs Grizzlies Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.