Memphis Grizzlies vs Boston Celtics Prediction - 11/12/2025
Updated November 12, 2025
Updated November 12, 2025
The Memphis Grizzlies will face the Boston Celtics on Wednesday night in a game that both teams could really use. Both squads are under the .500 mark for the year and need to find a way to build some momentum going forward. Boston is the favorite on their home floor and will try to take advantage of fatigue issues for the Grizzlies. Here, I break down this inter-conference matchup and make my Grizzlies vs Celtics prediction.
Boston is navigating through a season‑opening slump. They have a 5‑7 record and they are coming off a loss in Philadelphia on Tuesday night. The Grizzlies are also struggling and on the second night of a back-to-back in this game. Memphis is 4-8 on the season and took a double-digit loss at the hands of the New York Knicks on Tuesday. Both teams will have to get the job done on tired legs tonight.
The Grizzlies’ injury list is concerning. Brandon Clarke is out with knee synovitis. Ty Jerome is projected to miss at least four weeks with a strained calf. Scotty Pippen Jr. is sidelined with a toe issue. Zach Edey is listed day‑to‑day with an ankle injury and could make his return in this contest, providing some much-needed optimism. Boston is without Jayson Tatum (Achilles) and is leaning on Jaylen Brown, Derrick White, and the supporting cast to step up in his absence.
Player | Prop |
|---|---|
Jaylen Brown (BOS) | Over 25.5 Points |
Derrick White (BOS) | Over 3.5 Made Threes |
Ja Morant (MEM) | Under 7.5 Assists |
Score Projection: Memphis Grizzlies 104 – Boston Celtics 114
Win Probability: Memphis 30%, Boston 70%
Both of these teams have to overcome playing on Tuesday night in order to get a win here. But I think that the Celtics have the advantage at home in this game. Even if Edey comes back for the Grizzlies, he should be limited in terms of his workload in his return. I'll lay the points with Boston and bank on their superior three-point shooting to help them get a much-needed win at TD Garden.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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