Cleveland Cavaliers vs San Antonio Spurs Best Bet & Predictions – 12/29/2025

The Cleveland Cavaliers will take on the San Antonio Spurs on Monday night in an inter-conference matchup in the NBA. The Spurs have been one of the NBA’s top teams this season, yet they will be tasked with bouncing back from a shocking loss in their last outing here. Cleveland’s dynamic duo of Donovan Mitchell and Darius Garland is on the floor together again and will try to upset the Spurs in San Antonio. Before tip-off from Texas, you will find my Cavaliers vs Spurs prediction below.

Our Cavaliers vs Spurs Pick

Game Snapshot

• Matchup: Cleveland Cavaliers @ San Antonio Spurs
• Date & Time: Monday, December 29, 2025, 8:00 PM ET
• Venue: Frost Bank Center, San Antonio, Texas
• Broadcast: NBC and Peacock

Key Storylines

• The Spurs enter this game at 23-8, sitting near the top of the Western Conference, but their eight-game winning streak was recently broken by the Utah Jazz. A loss at home to a bad Jazz team was a shock and it will be up to the Spurs to try and rebound from that disappointing performance here.
• San Antonio is expected to have Victor Wembanyama and Stephon Castle available, with De’Aaron Fox listed as questionable after missing time with a minor adductor issue. The availability of Fox will impact the team’s offensive rhythm and assist creation if he’s unable to go.
• Cleveland comes in at 17-16 and on a three-game road trip. They lost their last two games, including recent defeats to the Houston Rockets and New York Knicks. But the Cavs remain dangerous offensively when Donovan Mitchell is hot. Mitchell is averaging 30.7 points per game and his shooting will be very important to the chances of the Cavs here.
• The Cavaliers will be without Larry Nance Jr. and Max Strus due to injuries. But the Cavs have Evan Mobley and Darius Garland back on the floor, which is much more important than the presence of Nance and Strus.

Head-to-Head & Betting Trends

• The Cavs defeated the Spurs by 13 points in Cleveland in their first meeting of the season.
• The Cavs are an NBA-worst 10-23 against the spread this season.
• The Spurs are 17-13-2 against the spread going into this matchup.
• Cleveland is 16-17 in the over/under market so far this year, slightly favoring the under.
• The Spurs are 16-16 on over/unders this year.

Best Player Props to Watch

Cavaliers vs Spurs Model Projection

Final Thoughts

Jay Sanin

Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.