Missouri Tigers vs Oklahoma Sooners Prediction - 11/22/2025
Updated November 21, 2025
Updated November 21, 2025
The Missouri Tigers hit the road to take on the Oklahoma Sooners in an important SEC matchup on Saturday afternoon. Missouri enters with a 7-3 record and will try to overcome the injury concerns for their starting quarterback to pull off an upset. Oklahoma is 8-2 and relies on one of the top defenses in the nation. Here, I break down this matchup in the SEC and give you my Missouri vs Oklahoma prediction.
The biggest storyline going into this game is the fact that Oklahoma is in a great spot to make this year's College Football Playoff. The Sooners are ranked inside of the top 10 after taking down Alabama on the road last week. If Oklahoma can deliver at home in this contest, they will be a win away from likely qualification for the playoff as an at-large team.
Missouri’s punishing ground game will need to be at its best against Oklahoma’s elite defense. The Tigers are ranked 23rd in the country and boast one of the most efficient rushing attacks in the country, averaging 232.3 rushing yards per game. Oklahoma’s defense surrenders just 14.8 points per game. With Beau Pribula listed as questionable, Mizzou needs to find a way to move the ball on the ground.
Both of these teams are more or less out of contention in the race for the SEC title game. Oklahoma might not need to make it to Atlanta to get an at-large selection into the playoffs. And for Missouri, the goal at this point is just to maximize their chances of landing in a marquee bowl game for their program.
Missouri’s quarterback situation remains a concern. Beau Pribula has been upgraded to questionable for this matchup. Freshman Matt Zollers stepped in while Pribula was out, but he lacks the upside and experience to pressure a top-tier Oklahoma defense. The Tigers will hope that Pribula is good to go in this contest.
Oklahoma's John Mateer manages the offense with poise. He’s not flashy, but he avoids big mistakes and allows his defense to set the tone. His recent performance against Alabama (138 yards, no interceptions) is a good example of game management under pressure.
Score Projection: Oklahoma 24 – Missouri 17
Win Probability: Oklahoma 75%, Missouri 25%
We should see a defensive battle in this game whether or not Pribula is good to go for Missouri. My best bet for this matchup is for the under to hit, as both teams should get plenty of stops in a game that Oklahoma should ultimately win on its home turf.
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