Cincinnati vs Kansas Pick & Prediction - 9/27/2025
Updated September 25, 2025
Updated September 25, 2025
The Cincinnati Bearcats (2–1) will travel to Lawrence to face the Kansas Jayhawks (3–1) on Saturday afternoon. Kansas already has a Big 12 win under its belt to start the season, while Cincinnati is playing its first conference game of the season here. Before these conference rivals take the field on Saturday, continue reading to get my thoughts on this matchup, including my Cincinnati vs Kansas prediction on the gridiron.
Odds | Spread | Moneyline | Total |
|---|---|---|---|
Cincinnati | +4.5 | +160 | Over 57.5 |
Kansas | -4.5 | -190 | Under 57.5 |
Brendan Sorsby has been a dual-threat for Cincinnati, leading the team with 655 passing yards and 175 rushing yards. He has accounted for 12 total touchdowns between passing and rushing scores and Kansas will need to be hyper-vigilant to prevent him from breaking containment. Kansas' Jalon Daniels has been sharp this season as well. He has completed two-thirds of his passes on the year and has 12 passing touchdowns to just two interceptions.
Score Projection: Kansas 34 – Cincinnati 24
Win Probability: Kansas 69.2%, Cincinnati 30.8%
While Cincinnati's offense has been impressive, Kansas' balanced attack and strong defensive play give them the edge in this matchup. The Jayhawks' ability to control the game on both sides of the ball, along with their home-field advantage, make them a solid pick to cover the spread as far as I'm concerned. Cincinnati will experience some regression on offense against a power conference opponent and the Jayhawks will move to 2-0 in Big 12 play.
Jay Sanin is the GM and Head of Sports at ATS.io. He has been writing about sports gambling since 2013, handicapping tens of thousands of sporting events. He plays sides and totals aggressively across most sports and is more selective in player prop markets. He does his own modeling across most sports, and his family is jealous of how much time he spends on his precious spreadsheets.
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