The Creighton Bluejays travel to Cincinnati on Wednesday to open Big East conference competition against the Xavier Musketeers. Creighton enters with a 5-5 record and a need for consistency after dropping its last two games, while Xavier has built momentum with an 8-3 mark and a strong home resume. Before tip-off in the opener of the Big East season for both of these teams, continue reading to find my Creighton vs Xavier prediction.
Our Creighton vs Xavier Pick
Game Snapshot
- Matchup: Creighton Bluejays @ Xavier Musketeers
- Date & Time: December 17, 2025, 6:30 PM ET
- Venue: Cintas Center, Cincinnati, Ohio
- Broadcast: FS1
Key Storylines
Coming out of non-conference play, Xavier has some clear advantages. They enter conference play with a 7-1 record at home and a five-game winning streak that sets a positive tone entering Big East play. The Musketeers’ offense is averaging 78.4 points per game. Their effectiveness stems from a mix of inside presence and perimeter scoring, led by Tre Carroll. Carroll is averaging 16.9 points and 5.7 rebounds per game. The Musketeers appear more cohesive under first-year head coach Richard Pitino.
Meanwhile, Creighton arrives with a .500 record and a three-game road losing streak that includes losses to quality opponents like the Nebraska Cornhuskers. The Bluejays have shown offensive potential, shooting well from beyond the arc, but inconsistency and defensive lapses have hindered their efforts. Without star big man Ryan Kalkbrenner from last season, now in the NBA, Creighton’s roster is still finding its identity in this campaign.
Head-to-Head & Betting Trends
- Xavier is 23-20 all-time against Creighton going into this contest.
- Creighton is just 3-7 against the spread going into this matchup.
- Xavier is 5-6 against the spread entering Wednesday night.
- The under has cashed in 9 of the 10 games involving Creighton.
- Xavier has gone over the total in 6 of their first 11 games.
Creighton vs Xavier Model Projection
Final Thoughts
