After winning their first two games of the season, the San Francisco 49ers find themselves at 2-2 heading into Week 5. They take on an undefeated Arizona Cardinals team that has passed every test in front of them with flying colors. This week, we make NFL picks for 49ers vs Cardinals, an NFC West matchup that will have huge implications on the playoff chase in the league’s best division.
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49ers vs Cardinals Betting Pick
This game will be played at State Farm Stadium at 4:25 PM ET on Sunday, October 10, 2021.
Why Bet The Cardinals:
✅ There is quarterback uncertainty taking place with the San Francisco 49ers heading into this game. Jimmy Garoppolo is dealing with an injury that could see him sidelined for this game. Either way, the Cardinals are the best bet in this game regardless of who starts at quarterback for the 49ers.
✅ So far this season, the Arizona Cardinals are averaging about a yard per play more than the San Francisco 49ers. Their offense is vastly more explosive than that of the Niners to this point in the year, which will only become more evident if the 49ers are forced to start a rookie in Trey Lance.
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✅ While the 49ers are 2-2 on the season, their record requires some context to understand. They have beaten two teams in the Lions and Eagles with a combined one win on the season. Their two games against quality competition have resulted in losses, which is what will happen in this game also.
San Francisco 49ers
The San Francisco 49ers dropped their second game in as many weeks when they fell to the Seattle Seahawks at home in Week 4. In that game, Jimmy Garoppolo was injured, forcing Trey Lance to finish out the game at the quarterback position. Against Arizona, the status of Garoppolo is uncertain, as it is possible that either 49ers quarterback will be put on the field for this matchup.
Since the Niners improved to 2-0 on the season by beating the Philadelphia Eagles, they have struggled on defense against the Packers and Seahawks. At 2-2 on the year, San Francisco sits in last place in the NFC West. A loss here against the Cardinals would put them below .500 and three games behind the Cardinals for first place in the division, which would feel like a death sentence.
Arizona Cardinals
Last week, the Arizona Cardinals improved to 4-0 on the year when they walloped the Los Angeles Rams on the road. Kyler Murray continued a start to the season that should put him at or near the top of any MVP conversations in the league. But that start could be easily wasted if the Cardinals don’t take care of business at home in winnable games against teams like the Niners.
Week 4 was the best defensive performance of the season for the Cardinals so far, as they were able to severely limit the impact of Matt Stafford and the passing game for the Rams. If they can do something similar against San Francisco, a 5-0 start should be attainable. But this is a rough stretch of the Cardinals’ schedule, with a game against the Browns lined up for next week, which could make it hard for the Cardinals to keep up their current level of play.