On Tuesday, the Memphis Grizzlies (4–10) make the trip to San Antonio to face the 9–4 Spurs. Both teams are dealing with injury issues going into this matchup, while the Grizzlies are struggling in several other key areas as well. Before tip-off from Texas, continue reading to get my Grizzlies vs Spurs prediction for this contest.
Our Grizzlies vs Spurs Pick
Pick: Spurs −5.5
Confidence: ★★★★☆
Game Snapshot
- Matchup: Memphis Grizzlies @ San Antonio Spurs
- Date & Time: Tuesday, November 18, 2025, 8:00 PM ET
- Venue: Frost Bank Center, San Antonio, Texas
- Broadcast: NBC / Peacock
Key Storylines
- San Antonio’s injury setbacks: The Spurs will be without Victor Wembanyama, who is dealing with a calf strain and is expected to miss several weeks. This is a major blow, as he’s a key presence on both ends of the floor. On top of that, Stephon Castle (hip) and Dylan Harper (calf) are also unavailable, placing more pressure on De’Aaron Fox and the Spurs’ supporting cast.
- Memphis’ depleted backcourt: The Grizzlies are also in a bind. Ja Morant remains out, and other ball-handlers like Scotty Pippen Jr. are banged up, limiting their ability to run their offense effectively. The Grizzlies have a 4–10 record and they’re near the bottom of the league in several key offensive metrics.
- Bigs battle: Without Morant, Memphis will lean more on Jaren Jackson Jr. and Zach Edey. Meanwhile, San Antonio will need its frontcourt of Luke Kornet, Kelly Olynyk, and Jeremy Sochan to step up in Wembanyama’s absence.
Head-to-Head & Betting Trends
- This is the first of four regular-season games scheduled between Memphis and San Antonio this season.
- San Antonio is 5-6-2 against the spread so far this season.
- Memphis is 4-10 against the spread going into this game.
- The over is 7-6 in the Spurs’ first 13 games of the season.
- The under has cashed in 9 of Memphis’ first 14 games.
Best Player Props to Watch
| Player | Prop to Watch |
|---|---|
| De’Aaron Fox | Over 26.5 points |
| Jaren Jackson Jr. | Over 22.5 points |
| Luke Kornet | Over 7.5 rebounds |
Grizzlies vs Spurs Model Projection
Score Projection: Grizzlies 112 – Spurs 122
Win Probability: Spurs 63%, Grizzlies 37%
Final Thoughts
San Antonio is the play here, even without Wembanyama. The injury to their star big man is huge for the Spurs, but this Grizzlies team is also far from healthy. Memphis’ lack of playmaking and scoring, combined with San Antonio’s depth in the paint, suggests the Spurs should be able to handle their adversity here. I’ll lay the points with the Spurs in this nationally-televised contest.
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