The upcoming clash between the Duke Blue Devils and the UConn Huskies on Saturday is a battle of two basketball schools on the football field. Duke arrives at 5‑3 after a wild 46‑45 win over the Clemson Tigers and are chasing bowl eligibility. UConn stands at 6‑3 and is fighting for back‑to‑back winning seasons for the first time in over a decade. Before these two teams meet at Pratt & Whitney Stadium in East Hartford, continue reading to get my Duke vs UConn prediction.
Our Duke vs UConn Pick
- Pick: Over 63.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Duke Blue Devils vs UConn Huskies
- Date & Time: Saturday, November 8, 2025, 3:30 p.m. ET
- Venue: Pratt & Whitney Stadium at Rentschler Field, East Hartford, CT
- Broadcast: CBS Sports Network
Key Storylines
Duke’s recent 46‑45 win over Clemson shows they can light up the scoreboard but also that their defense is vulnerable to getting lit up. UConn rebounded from a double overtime loss to Rice with a 38‑19 win over UAB last time out.
The fact that both teams have one of the nation’s better passing offenses means this game has shootout potential. Duke is 43rd in SP+ rankings, while UConn’s sits in 57th. That indicates a slight edge for Duke in overall efficiency, but home field and UConn’s potent offense could make this a tight game.
Quarterback Play
This game features two gifted passers in Duke’s Darian Mensah and UConn’s Joe Fagnano. Both have eclipsed 2,500 yards passing so far this season and both have over 20 touchdowns through the air on the season. Mensah has two interceptions and Fagnano has yet to throw one. This should be a very good matchup if you like high-powered passing attacks.
Betting Trends
- Duke is 4-4 against the spread going into this game.
- UConn is 4-4-1 against the spread in their games going into Saturday.
- Duke has gone over the total in six of its first eight games.
- UConn is 6-3 favoring the over so far this season.
- Duke beat UConn 26‑21 in 2024. UConn’s record against ACC teams stands at an abysmal 9‑29.
Duke vs UConn Model Projection
Score Projection: Duke 38 – UConn 31
Win Probability: Duke 72% | UConn 28%
Final Thoughts
Duke should be able to get the win against UConn on Saturday. But my best bet for this contest is for the over to cash instead. We should see both teams move the ball through the air early and often in this matchup and I’ll take the over while cheering for Mensah and Fagnano to throw it all over the field with little resistance.
