The Virginia Cavaliers and Northwestern Wildcats will meet on Friday in the Skechers Greenbrier Tip-Off. Both teams enter undefeated at 4–0. Virginia has looked sharp under new head coach Ryan Odom, while Northwestern has leaned heavily on its experienced backcourt to build momentum. Here, I have broken down this matchup from West Virginia and you can find my Virginia vs Northwestern prediction below.
Our Virginia vs Northwestern Pick
- Pick: Northwestern +4.5
- Confidence: ★★★★☆
Game Snapshot
- Matchup: Northwestern Wildcats vs Virginia Cavaliers
- Date & Time: Friday, November 21, 2025, 5:00 PM ET
- Venue: Colonial Hall, White Sulphur Springs, West Virginia
- Broadcast: CBS Sports Network
Key Storylines
- Virginia’s new era under Ryan Odom. After Tony Bennett’s retirement, Odom has injected pace and offensive versatility into the Cavaliers, resulting in a robust scoring average of 90.8 points per game so far. Their fast start includes a 104-point outing against Marshall. But they also haven’t faced any power conference competition until this game and regression could happen here.
- Dominant frontcourt play. Virginia’s frontcourt, anchored by Thijs De Ridder and Johann Grünloh, has size, shot-blocking, and the ability to stretch the floor. De Ridder is averaging 17.3 points per contest to lead the Cavaliers this season.
- Northwestern’s backcourt firepower. The Wildcats are being carried by Nick Martinelli and Arrinten Page. Martinelli is averaging a team-high 20.5 points per game, while Page is giving the Wildcats 8.3 rebounds per game to lead the team.
- Mismatches defensively. Odom has noted the challenge of Northwestern’s switching defense, as well as their aggressive doubling in the post. Virginia will need to be disciplined to overcome that in their first real test under Odom.
- Neutral site implications. Though Virginia leads the historical series 3–0, this is their first-ever neutral-site meeting.
Betting Trends
- Virginia is 3-1 against the spread going into this game.
- Northwestern is 2-2 against the spread so far this season.
- The Hoos have gone under the total in three of their first four games this season.
- Northwestern has gone 2-2 in the over/under market to start the year.
Virginia vs Northwestern Model Projection
- Projected Final Score: Virginia 75 – Northwestern 73
- Win Probability: Virginia 69%, Northwestern 31%
Final Thoughts
Both of these teams are off to nice starts this season, though it is hard to judge either of them given that neither team has played any high-quality competition just yet. I think that the veteran leadership of Northwestern will help them to handle this neutral-site matchup well. I’ll go with Northwestern to cover the spread as an underdog in a game that could go either way.
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