The Houston Cougars (5–0) head into a marquee showdown against the Syracuse Orange (4–0) on Monday in Las Vegas. This game serves as the opener for both teams in the Players Era Festival at the MGM Grand Garden Arena. Houston is a heavy favorite in this neutral-site matchup and Syracuse will try to trip them up in their first game outside of Syracuse this season. Before tip-off from Vegas, continue reading to find my Syracuse vs Houston prediction below.
Our Syracuse vs Houston Pick
- Pick: Houston -11.5
- Confidence: ★★★★☆
Get more college basketball picks before today’s games!
Game Snapshot
- Matchup: Syracuse Orange vs Houston Cougars
- Date & Time: Monday, November 24, 2025, 6:00 PM ET
- Venue: MGM Grand Garden Arena, Las Vegas, NV
- Broadcast: TNT
Key Storylines
- Houston’s early dominance: The Cougars are 5–0 to start the season, getting strong performances across the board. Guard Emanuel Sharp recently notched his 100th career win and is averaging around 16.0 points per game. Freshman point guard Kingston Flemings has been electric, leading Houston with 17.4 PPG, 5.2 APG, and an absurd 71.4% on field goals.
- Syracuse’s stingy defense: The Orange are allowing just 53.2 points per game while holding opponents to a 30.9% field goal rate. Those are numbers that lead Division I in those respective categories. Their defensive identity could force Houston into tougher possessions than usual. But Syracuse has also run over small schools like Binghamton early in the season and they could have a tougher time against an actual powerhouse program.
- Pressure on Houston in a neutral setting: The pressure is on Houston going into this game. They are the team ranked second in the country and they are the team with the high expectations heading into this matchup. Syracuse will be able to play fast and free without having to worry about expectations going into this contest.
- Syracuse’s soft schedule to date: While Syracuse is 4–0, their competition has been relatively weak. The Orange have played the weakest schedule in all of Division I during non-conference play, according to KenPom. That could mean a rude awakening for the Orange here as they are no longer playing cupcakes.
Head-to-Head & Betting Trends
- The two teams have met twice previously, with each team winning once. Their most recent meeting came in the 2021 NCAA Tournament Sweet 16, when Houston won 62–46.
- Houston is 2-3 against the spread going into this matchup.
- Syracuse is 3-1 against the spread thus far.
- The under has cashed in three of Syracuse’s first four games.
- Houston is 2-3 to the under through five outings.
Syracuse vs Houston Model Projection
Score Projection: Houston 79 – Syracuse 64
Win Probability: Houston 88%, Syracuse 12%
Final Thoughts
Houston should have a huge edge in this matchup against Syracuse. The Orange are undefeated, but they haven’t played anyone capable of threatening them yet. They should struggle here against a Houston team that is ranked as the best defensive team in all of college basketball according to KenPom. Houston should shut down Syracuse and win big in Vegas.
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